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Chlorpropamide’s plasma half-life may be prolonged by Zyloprimsince Zyloprim and chlorpropamide may compete for excretion in the renal tubuleThe risk of hypoglycemia secondary to this mechanism may be increased if Zyloprim and chlorpropamide are given concomitantly in the presence of renal insufficiency.

Zyloprim reduces the production of uric acid in your bodyUric acid buildup can lead to gout or kidney stones.

Zyloprim can lower blood cells that help your body fight infectionsThis can make it easier for you to bleed from an injury or get sick from being around others who are illYour blood may need to be tested oftenVisit your doctor regularly.

Zyloprim can substantially reduce serum and urinary uric acid levels in previously refractory patients even in the presence of renal damage serious enough to render uricosuric drugs virtually ineffectiveSalicylates may be given conjointly for their antirheumatic effect without compromising the action of ZyloprimThis is in contrast to the nullifying effect of salicylates on uricosuric drugs.

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