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A single-dosemetformin-nifedipine drug interaction study in normal healthy volunteers demonstrated that coadministration of nifedipine increased plasma metformin C max and AUC by 20and 9respectivelyand increased the amount excreted in the urineT max and half-life were unaffectedNifedipine appears to enhance the absorption of metforminMetformin had minimal effects on nifedipine.

Periodic fasting blood glucoseFBGand HbA 1c measurements should be performed to monitor therapeutic response.

The hypoglycemic action of sulfonylureas may be potentiated by certain drugsincluding nonsteroidal anti-inflammatory agents and other drugs that are highly protein boundsalicylatessulfonamideschloramphenicolprobenecidcoumarinsmonoamine oxidase inhibitorsand beta-adrenergic blocking agentsWhen such drugs are administered to a patient receiving Glucovancethe patient should be observed closely for hypoglycemiaWhen such drugs are withdrawn from a patient receiving Glucovancethe patient should be observed closely for loss of blood glucose control.

Patients at risk for lactic acidosis include those with reduced function of the:

There are no adequate studies in pregnant womenMost experts agree that insulin is the best treatment for pregnant women with diabetesMetformin is excreted into breast milk and can therefore be transferred to the nursing infantNursing mothers should not use metformin.

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