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Instruct patients to inform their doctor that they are taking Glucovance prior to any surgical or radiological procedureas temporary discontinuation of Glucovance may be required until renal function has been confirmed to be normalsee PRECAUTIONS

An enzyme deficiency called glucose-6-phosphate dehydrogenase deficiencyG6PD

During pregnancythis medication should be used only when clearly neededPregnancy may cause or worsen diabetesDiscuss a plan with your doctor for managing your blood sugar while pregnantYour doctor may substitute insulin for this product during pregnancyIf you are using glyburide during your pregnancyyour doctor may switch you to insulin at least 2 weeks before the expected delivery date because of glyburide’s risk of causing low blood sugar in your newbornDiscuss the risks and benefits with your doctor.

Take the Diabetes Quiz and learn the causessignssymptomsand types of this growing epidemicWhat does diabetes have to do.

Glucovance is capable of producing hypoglycemia or hypoglycemic symptomsthereforeproper patient selectiondosingand instructions are important to avoid potential hypoglycemic episodesThe risk of hypoglycemia is increased when caloric intake is deficientwhen strenuous exercise is not compensated by caloric supplementationor during concomitant use with other glucose-lowering agents or ethanolRenal or hepatic insufficiency may cause elevated drug levels of both glyburide and metformin hydrochlorideand the hepatic insufficiency may also diminish gluconeogenic capacityboth of which increase the risk of hypoglycemic reactionsElderlydebilitatedor malnourished patients and those with adrenal or pituitary insufficiency or alcohol intoxication are particularly susceptible to hypoglycemic effectsHypoglycemia may be difficult to recognize in the elderly and people who are taking beta-adrenergic blocking drugs.

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